Showing 17 out of 17 cruises
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Range: £0 - £5000+

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Fly Cruise From:
£6239pp

Panoramic Panama Canal

San Diego | San Diego | San Diego | Cabo San Lucas | Cabo San Lucas | Zihuatanejo | Zihuatanejo | Puerto Quetzal | Corinto | Puntarenas | Puntarenas | Puntarenas | Cartagena | Cartagena | Georgetown | Georgetown | Miami | Port Canaveral | Port Canaveral | New York | New York

  • 03 Jul 2025
  • 20 Nights
Fly Cruise From:
£6239pp
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Fly Cruise From:
Was £3759pp Now: £3571pp

Pacific Pathways

Los Angeles | Ensenada | Cabo San Lucas | Acapulco | Puerto Quetzal | Corinto | Puntarenas | Puntarenas | Colón

  • 02 Nov 2025
  • 12 Nights
Fly Cruise From:
Was £3759pp Now: £3571pp
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Fly Cruise From:
Was £6369pp Now: £6050pp

Pacific Pathways

Colón | Colón | Puntarenas | Corinto | Puerto Quetzal | Acapulco | Cabo San Lucas | Ensenada | Los Angeles

  • 14 Nov 2025
  • 12 Nights
Fly Cruise From:
Was £6369pp Now: £6050pp
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Fly Cruise From:
Was £6387pp Now: £6067pp

Palms To Andean Peaks

Miami | Cozumel | Costa Maya | Belize City | Harvest Caye | Santo Tomás de Castilla | Roatán Island | Puerto Limón | Panama City | Puerto Limón | Panama City | Manta | Guayaquil | Salaverry | Callao | Coquimbo | San Antonio | San Antonio

  • 29 Nov 2025
  • 22 Nights
Fly Cruise From:
Was £6387pp Now: £6067pp
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Fly Cruise From:
Was £10959pp Now: £10411pp

Iconic Isles To Icebergs

Miami | Cozumel | Costa Maya | Belize City | Harvest Caye | Santo Tomás de Castilla | Roatán Island | Puerto Limón | Panama City | Puerto Limón | Panama City | Manta | Guayaquil | Salaverry | Callao | Coquimbo | San Antonio | San Antonio | Puerto Montt | Castro | Puerto Chacabuco | Laguna San Rafael National Park | Laguna San Rafael National Park | Laguna San Rafael National Park | Punta Arenas | Ushuaia | Ushuaia | Ushuaia | Ushuaia | Ushuaia | Port Stanley | Puerto Madryn | Buenos Aires

  • 29 Nov 2025
  • 42 Nights
Fly Cruise From:
Was £10959pp Now: £10411pp
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Fly Cruise From:
Was £13259pp Now: £12596pp

Odyssey To World's End

Miami | Cozumel | Costa Maya | Belize City | Harvest Caye | Santo Tomás de Castilla | Roatán Island | Puerto Limón | Panama City | Puerto Limón | Panama City | Manta | Guayaquil | Salaverry | Callao | Coquimbo | San Antonio | San Antonio | Puerto Montt | Castro | Puerto Chacabuco | Laguna San Rafael National Park | Laguna San Rafael National Park | Laguna San Rafael National Park | Punta Arenas | Ushuaia | Ushuaia | Ushuaia | Ushuaia | Ushuaia | Port Stanley | Puerto Madryn | Buenos Aires | Buenos Aires | Montevideo | Punta del Este | Itajai | Porto Belo | Santos | Parati | Ilha Grande | Buzios | Rio de Janeiro | Rio de Janeiro

  • 29 Nov 2025
  • 54 Nights
Fly Cruise From:
Was £13259pp Now: £12596pp
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Fly Cruise From:
Was £7309pp Now: £6943pp

A Tale Of Two Seas

Miami | Port Royal | Santa Marta | Cartagena | Cartagena | Puntarenas | San Juan del Sur | Acajutla | Puerto Quetzal | Huatulco (Santa María Huatulco) | Puerto Vallarta | Los Angeles

  • 03 Dec 2025
  • 17 Nights
Fly Cruise From:
Was £7309pp Now: £6943pp
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Fly Cruise From:
Was £4159pp Now: £3951pp

Passage To Panama

Miami | Cozumel | Costa Maya | Harvest Caye | Santo Tomás de Castilla | Roatán Island | Puerto Limón | Panama City | Puerto Limón | Panama City

  • 17 Jan 2026
  • 10 Nights
Fly Cruise From:
Was £4159pp Now: £3951pp
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Fly Cruise From:
Was £5969pp Now: £5670pp

Caribbean Kaleidoscope

Miami | Cozumel | Costa Maya | Harvest Caye | Santo Tomás de Castilla | Roatán Island | Puerto Limón | Panama City | Puerto Limón | Panama City | Panama City | Panama City | Cartagena | Kralendijk | Willemstad | Oranjestad | Port Antonio | Miami

  • 17 Jan 2026
  • 20 Nights
Fly Cruise From:
Was £5969pp Now: £5670pp
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Fly Cruise From:
Was £3989pp Now: £3789pp

Canal & Caribbean Discovery

Panama City | Panama City | Panama City | Cartagena | Kralendijk | Willemstad | Oranjestad | Port Antonio | Miami

  • 27 Jan 2026
  • 10 Nights
Fly Cruise From:
Was £3989pp Now: £3789pp
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Fly Cruise From:
Was £4359pp Now: £4141pp

Palms & Panama Canal

Tampa | Cozumel | Costa Maya | Belize City | Roatán Island | Puerto Limón | Colón | Panama City | Colón | Panama City

  • 25 Mar 2026
  • 10 Nights
Fly Cruise From:
Was £4359pp Now: £4141pp
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Fly Cruise From:
Was £6229pp Now: £5917pp

Panama Canal Connoisseur

Tampa | Cozumel | Costa Maya | Belize City | Roatán Island | Puerto Limón | Colón | Panama City | Colón | Panama City | Panama City | Cartagena | Willemstad | Oranjestad | Montego Bay | Georgetown | Miami

  • 25 Mar 2026
  • 20 Nights
Fly Cruise From:
Was £6229pp Now: £5917pp
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Fly Cruise From:
Was £4049pp Now: £3846pp

Classic Canal & Tropics

Panama City | Panama City | Cartagena | Willemstad | Oranjestad | Montego Bay | Georgetown | Miami

  • 04 Apr 2026
  • 10 Nights
Fly Cruise From:
Was £4049pp Now: £3846pp
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Fly Cruise From:
Was £4219pp Now: £4008pp

Vivid Western Caribbean

Miami | Cozumel | Costa Maya | Belize City | Roatán Island | Puerto Limón | Colón | Panama City | Colón | Panama City

  • 14 Apr 2026
  • 10 Nights
Fly Cruise From:
Was £4219pp Now: £4008pp
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Fly Cruise From:
Was £3989pp Now: £3789pp

Canal & Coral Isles

Panama City | Panama City | Cartagena | Puerto Limón | Roatán Island | Costa Maya | Cozumel | Miami

  • 24 Apr 2026
  • 10 Nights
Fly Cruise From:
Was £3989pp Now: £3789pp
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Cruise Only From:
Was £2569pp Now: £2440pp

Panama Potpourri

Miami | Cozumel | Costa Maya | Harvest Caye | Santo Tomás de Castilla | Roatán Island | Puerto Limón | Panama City | Puerto Limón | Panama City

  • 05 Jan 2027
  • 10 Nights
Cruise Only From:
Was £2569pp Now: £2440pp
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Cruise Only From:
Was £2569pp Now: £2440pp

Panama Potpourri

Miami | Cozumel | Costa Maya | Harvest Caye | Santo Tomás de Castilla | Roatán Island | Puerto Limón | Panama City | Puerto Limón | Panama City

  • 05 Mar 2027
  • 10 Nights
Cruise Only From:
Was £2569pp Now: £2440pp
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Prices are subject to change and availability. Prices may vary depending on the airport selected. Promotions are only applicable to select cabin grades, please call for details.

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This website will provide you with information on the financial protection that applies in the case of each holiday and travel service offered before you make your booking. At the time of booking, our Cruise Concierge will also confirm the financial protection applicable to your specific holiday. Please ask us for further information should you require it. The flight inclusive holidays on this website are financially protected by the ATOL scheme. But ATOL protection does not apply to all holiday and travel services listed on this website. If you do not receive an ATOL Certificate then the booking will not be ATOL protected. If you do receive an ATOL Certificate but all parts of your trip are not listed on it, those parts will not be ATOL protected. The cruise-only holidays on this website are financially protected by ABTA. Please see our booking terms and conditions for further information or for more information about financial protection and the ATOL Certificate, click here. SixStarCruises acts as a retail agent to you and also as a disclosed agent of the holiday provider (the Organiser of the holiday). The Foreign & Commonwealth Office have up-to-date advice on staying safe and healthy abroad. Visit the foreign travel advice site for the latest travel updates.

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